牛牛赌博作弊:普通牌牛牛电脑分析仪

普通牌牛牛电脑分析仪 www.yxkda.icu

您當前位置:醫院首頁 > 科研動態
全軍創傷修復與組織再生重點實驗室-感染與免疫學實驗室簡介
作者:本站編輯  來源:本站原創  發布時間:2015-08-30 13:08:06

全軍創傷修復與組織再生重點實驗室

-創傷感染與免疫學實驗室簡介

創傷感染與免疫學實驗室(平臺)是全軍創傷修復與組織再生重點實驗室和北京市皮膚損傷修復與再生醫學重點實驗室的重要組成部分。主要從事創(燒、戰)傷后感染并發癥,包括嚴重膿毒癥、膿毒性休克與組織損害發病機制和診治策略的轉化研究。主要領域涉及細菌內/外毒素致病機制、免疫功能障礙及其監測、神經內分泌調節途徑、膿毒癥診治新技術研究等。

該實驗室主要學術成績包括:(1)系統闡明高遷移率族蛋白B1在創、燒傷膿毒癥發病中的確切作用與信號機制,首先提出其作為關鍵免疫調控分子誘發多器官損害的新觀點。(2)發現生物喋呤參與內/外毒素休克的病理生理過程,建立了新喋呤和內毒素的臨床預警閾值。(3)揭示了燒傷后金黃色葡萄球菌及其外毒素致病的臨床意義,在國際上最早報道殺菌/通透性增加蛋白對腸源性內毒素血癥具有重要防護效應。(4)提出評價嚴重燒傷免疫功能障礙程度的新標準,采用新的炎癥、免疫調理策略對嚴重膿毒癥進行干預,多中心試驗療效顯著優于“國際膿毒癥指南”推薦的方法。

實驗室緊緊圍繞以解決降低平時和戰時嚴重創(燒、戰)傷病死率中的關鍵科學問題開展研究,經過老中青三代近30年的建設、發展與凝練,逐步形成了嚴重膿毒癥和膿毒性休克發生機制與診治新途徑的研究特色與學術優勢。以盛志勇院士為代表的老一代科學家開創事業并奠定了堅實基礎,以國家杰出青年科學基金獲得者姚詠明研究員為代表的新一代專家推動和提升了科研團隊的創新發展。該研究方向現有固定工作人員為7人,其中正高職1名、副高職3名,每年在讀博士后、博士/碩士研究生以及客座研究人員20余人。姚詠明研究員為該研究方向負責人,清華大學、中山大學、南開大學等8所高??妥蚣嬤敖淌?。目前擔任國際休克學會執委、歐洲休克學會顧問、Shock雜志編委等?;衽分?、美國休克學會頒發的Schlag紀念獎、中國青年科技獎、“求是”杰出青年獎、“新世紀百千萬人才工程”國家級人選、“全國優秀科技工作者”和軍隊杰出專業技術人才獎,入選“科技北京”百名領軍人才工程等。主要學術骨干包括:(1)張慶紅,美國NIH博士后,副研究員,主持國家自然科學基金面上課題2項和軍隊“十二五”計劃重點課題1項。(2)祝筱梅,博士后,副研究員,北京市科技新星,主持國家自然科學基金課題2項;(3)董寧,醫學碩士,副主任技師,研究團隊的主要技術骨干。

實驗室成員承擔國家973項目課題、國家杰出青年科學基金、國家自然科學基金重點項目、國家自然科學基金面上和青年項目、軍隊杰出中青年人才基金、軍隊“十二五”計劃重點課題等37項;在國內外專業期刊發表學術論文480余篇,其中被SCI收錄112篇;主編大型學術著作5部,其中《現代膿毒癥理論與實踐》(177萬字)、《急危重癥病理生理學》(235萬字)分別為國內相關領域首部大型著作;共獲國際學術獎3項、國家科技進步二等獎4項、軍隊和省部級科技進步一等獎4項、二等獎8項。

該研究方向(平臺)主要功能單元包括:分子與細胞免疫學研究平臺、細菌內/外毒素檢測技術、神經生物及神經行為學分析、基因組學與蛋白質學研究平臺等。

 

姚詠明研究員

 

      

張慶紅副研究員    祝筱梅副研究員   董寧副主任技師

 

課題組分析實驗結果

 

Brief Introduction about Laboratory of Infection and Immunity

 

The research fields in this laboratory are focused on infection and immunity after severe trauma, burns, and war wounds, including the effect of hemorrhage and trauma on endotoxin response and its regulatory mechanisms, inflammatory cascade and subsequent sepsis induced by gram-positive bacteria and its exotoxin, and application of novel markers for diagnosis or prognosis in evaluation of organ functions as well as clinical course in septic complications. With both animal experiments and multicenter clinical trials, the ongoing study will be performed to investigate the potential mechanism and clinical significance of immune dysfunction in the pathogenesis of sepsis after severe burns and trauma. New theories concerning the criteria of different degree of immune dysfunction, and novel strategies would be formulated for the treatment of acute inflammation and immune regulation, in order to apply advantageous interventional measures.

We are greatly indebted to academician Zhi-Yong Sheng, the founder and academic guidance of the Laboratory of Infection and Immunity. The chief investigator of this laboratory is Prof. Yong-ming Yao, who is the winner of National Natural Science Outstanding Youth Foundation of China. A scientific research team is organized in the laboratory, with old experts in guidance, excellent young and middle-age staff as mainstay, and research staff of productive age and education as the structure of research staff.

At present, the laboratory is staffed by 7 scientific researchers and technicians, including 1 professor and 3 associated professors. The laboratory also enrolled more than 20 postdoctoral, doctoral, master graduate students and visiting researchers every year. In recent years, catching up with the international research progresses, the laboratory from time to time adjusted its research direction and obtained prominent progress and honor, such as the Schlag Memorial Award of International Shock Society, Qiushi Outstanding Youth Award, China Youth Science and Technology Award, New Century State Candidates for "Thousands Talent Project", Distinguished Young Scholars Supported by the National Science Fund, etc.

Since the establishment of the laboratory, we have published more than 480 scientific articles, with 112 by SCI source periodicals, and won 4 second class State Science and Technology Advancement Award. In addition, the members of this laboratory published 5 scholarly monographs as chief editor and 26 as editor.

 

 

 

 

預約掛號 智能導診
澳門金沙,澳門金沙城中心: 就醫指南